Colds ,Cough and flu are caused by viruses. Many symptoms are similar, and treatments for both are the same. Antibiotics won't help with a cold or the flu because they aren't effective against viruses. But Fruzen Tablet can help symptomatically as Fruzen Tablet contains Levocetirizine which is one of the best second generation antihistaminic with lesser sedative effect with greater potency than any other antihistamine. It blocks H 1 receptors and provide relief in allergic conditions .Phenylepherine acts as a nasal decongestant and helps in rapid relief of symptoms of nasal congestion and it consider to be most safest than any other decongestant . Patients who complain of fever, headache, and generalized body ache will be benefited from receiving a safe antipyretic - analgesic like Paracetamol. Moreover it contains caffine as it keep active and alerts even in day after having this medicine. The combination is safe, efficacious, time tested medicine which ensure temporary relief from cold symptoms, nasal congestion, runny nose, sore throat, sneezing, minor aches and pains, headaches and fever.

For Doctors

Each Tablet of FRUZEN Tablet contains:

Levocetirizine 2.5 mg
 Phenylephrine 10 mg
Paracetamol 325 mg
Caffeine 30 mg


Levocetirizine is a non-sedating, third generation antihistamine. It blocks the effects of histamine, which causes itching, sneezing, runny nose, and watery eyes. Levocetirizine also has inbuilt nasal decongestant action. It has reduced ant cholinergic and ant serotonin effects and therefore is preferred in patients with nasal congestion because it does not over dry nasal secretions. Phenylephrine acts on alpha-receptors causing vasoconstriction of blood vessels in the lining of the nasal passages and sinuses. This leads to shrinkage in turbinate size thereby decreasing resistance to nasal airflow and relieving a blocked nose. Phenylephrine also reduces the production of mucus. The actions of Levocetirizine and Phenylephrine compliment each other. While Levocetirizine works round the clock, Phenylephrine boosts the nasal decongestant action of Levocetirizine. Paracetamol is a well-established analgesic and antipyretic agent. Despite its widespread use for several decades, the exact mode of action is still not fully understood. However, it is thought that it works by reducing the production of prostaglandins in the brain and spinal cord. The body produces prostaglandins in response to injury and certain disease, which sensitize nerve endings, causing pain. Paracetamol reduces the production of these nerve-sensitizing prostaglandins and increases the pain threshold. Paracetamol reduces fever by affecting the hypothalamic heat-regulating center. Thus paracetamol in FRUZEN helps relieve aches, pain, sore throats and fever associated with rhinosinusitis, colds and flu. Caffeine is a mild stimulant that helps reduce fatigue. Caffeine also enhances the analgesic effect of paracetamol. The combination of levocetirizine, phenylephrine, paracetamol(FRUZEN) and caffeine in a single tablet of FRUZEN helps to relieve multiple symptoms of rhinosinusitis, colds and flu.


Rhino  sinusitis, colds, flu.

DOSAGE Adults and children >12 years: 1 tablet twice daily Children 6-12 years: ½ tablet twice daily

Fruzen Tablet is not recommended for
♦ Patients with known hypersensitivity to any ingredient in this product.
♦ Patients with end-stage renal impairment of less than 10 mL/min creatinine clearance or patients undergoing hemodialysis.
♦ Patients with overactive thyroid, high blood pressure or heart disease.
♦ Patients with severe hepatic dysfunction.


Fruzen Tablet should be given with care to patients with impaired kidney or liver function and patients taking other drugs that affect the liver.

♦ Dosage adjustment may be needed in patients 12 years of age and older with decreased renal function.

♦ Patients should be cautioned against engaging in hazardous occupations requiring complete mental alertness, and motor coordination such as operating machinery or driving a motor vehicle until their response to Fruzen is known.

♦ Patients with urinary retention, bladder-neck obstruction, or prostatic hypertrophy have the potential for exacerbation of urinary retention.

♦ Angle-closure glaucoma patients have the potential for increased intraocular pressure/precipitation of acute attack.


There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Fruzen should be used during pregnancy only if clearly needed.


As levocetirizine is excreted in breast milk, Fruzen is not recommended during breastfeeding. Pediatrics Do not exceed the recommended dose of 2.5 mg/day in children 6 to 12 years of age. The systemic exposure with the 5 mg dose is approximately twice that of adults. The safety and effectiveness of Fruzen in pediatric patients under 6 years of age have not been established.


FRUZEN should not be taken with:
♦ Other medicines including those containing paracetamol for the relief of flu, colds or congestion.
♦ Drugs for heart problems (including beta-blockers) or monoamine oxidase inhibitors (MAOIs) prescribed for depression


♦ In vitro data indicate that levocetirizine is unlikely to produce pharmacokinetic interactions through inhibition or induction of hepatic drug metabolizing enzymes.
♦ The co-administration of Monoamine Oxidase Inhibitors (MAOIs) or tricyclic antidepressants and an indirect or mixed-acting sympathomimetic may result in a hypertensive crisis and hence such concomitant use is best avoided.
 ♦ Additionally sympathomimetics may reduce the efficacy of beta-blocking and anti-hypertensive drugs.
♦ Anticoagulant drugs (warfarin) - dosage may require reduction if paracetamol and anticoagulants are taken for a prolonged period of time
♦ Paracetamol absorption is increased by substances that increase gastric emptying, e.g. metoclopramide
♦ Paracetamol absorption is decreased by substances that decrease gastric emptying, e.g. antidepressants with anticholinergic properties, and narcotic analgesics
♦ Paracetamol may increase chloramphenicol concentrations
♦ The risk of paracetamol toxicity may be increased in patients receiving other hepatotoxic drugs or drugs that induce liver microsomal enzymes such as alcohol and anticonvulsant agents
♦ Paracetamol excretion may be affected when given with probenecid
♦ Colestyramine reduces the absorption of paracetamol if given within 1 hour.
♦ Regular use of paracetamol possibly reduces metabolism of Zidovudine (increased risk of neutropenia).
♦ Smoking and drugs such as phenytoin, which induce hepatic microsomal metabolism result in an increase in caffeine clearance
♦ Drugs such as oral contraceptives reduce the rate of clearance by inhibiting caffeine metabolism.
♦ Caffeine elimination half-life has been reported to be increased and clearance decreased by the concomitant administration of ciprofloxacin.


FRUZEN is well tolerated. Side effects are mild and often transient.
The most common adverse reactions reported in clinical trials were: somnolence, nasopharyngitis, fatigue, dry mouth, and pharyngitis in subjects 12 years of age and older, and pyrexia, somnolence, cough, and epistaxis in children 6 to 12 years of age.
As a class, sympathomimetic amines may also cause headaches, vomiting, diarrhea, insomnia, restlessness and palpitations. However, there have been few reports of these with normal doses of Phenylephrine. Paracetamol rarely causes any problems but allergic reactions, such as skin rash, occasionally occur. There have been very rare reports of blood disorders but these were not necessarily caused by paracetamol. Caffeine may occasionally cause gastro-intestinal irritation and stimulation of the central nervous system.


Available in blister strips of 10 tablets

For Patients
Is Fruzen Tablet a over the counter?

No.Fruzen is not an over the counter medication. Prescription from your doctor is always required.

Is Fruzen Tablet a narcotic or steroid?

Fruzen Tablet  belongs to a class of medications called Anti cold Therapy. It is not a narcotic or steroid.

Is Fruzen Tablet safe in pregnancy and during breastfeeding?

Fruzen Tablet  is not safe during pregnancy or lactation. Patients should follow the advice of the doctor regarding its use.

Is Fruzen Tablet have decongestant Property ?

Yes it phenylepherine but with Levocetrizine it act as synergy it is  used to relieve runny nose; sneezing; and redness, itching, and tearing of the eyes caused by hay fever, seasonal allergies, and allergies due to other substances.

Is paracetamol in Fruzen Tablet is safe/ banned/ available in India?

Paracetamol in Fruzen Tablet given in recommended dosages of 325 mg . It is generally safe at prescribed doses.

Is paracetamol in Fruzen Tablet play role of a painkiller/ used for cold?

Paracetamol in Fruzen Tablet is used to relieve mild to moderate pain associated with cold and flu, as well as fever.

Does paracetamol in Fruzen Tablet make you drowsy / sleepy?

Paracetamol in Fruzen Tablet does not cause drowsiness. However, paracetamol is available in combination with cough and cold medicines (eg. Levocetirizine, chlorpheniramine), which may cause drowsiness or sleepiness.

what is role of Phenylephrine in Fruzen Tablet?

Phenylephrine in Fruzen Tablet  is a decongestant and is used to relieve blocked nose. Phenylephrine works for most of the patients if taken as recommended.

Is phenylephrine in Fruzen Tablet safe /make you drowsy/ high/ keep you up/ addictive/ thin blood/ cause constipation/affect birth control/ safe in pregnancy/ safe for breastfeeding?

Phenylephrine in Fruzen Tablet  is safe if taken at recommended dosage and duration. Some patients have been shown to have an upset stomach, drowsiness and other side effects. It can be addictive. It does not thin blood. It does not affect birth control. It should not be used during pregnancy or breastfeeding due to high risks.

Can i take Fruzen Tablet with high blood pressure?

Do not take Fruzen Tablet  with high blood pressure.

How Fruzen Tablet is safe than other anti cold therapy?

Fruzen Tablet  is safe as it contain Anti-Histamine Levocetrizine which has got less side effect of drowsiness like other. Phenylepherine in Fruzen tablets found to be safer than pseudoephedrine and Partacetamol is given in recommended dose of 325 mg to give relive from bodyache, fever.

What can I do to relieve my symptoms along with taking Fruzen Tablet?

•    Rest
•    Drink plenty of water and non-alcoholic fluids
•    Avoid exposure to cigarette smoke
•    Inhale steam to help relieve a blocked nose. Supervise your child while they breathe in steam from a hot bath or shower in a closed room.

You can help soothe a sore throat by:
•    gargling with warm salty water
•    sucking on an ice cube or a throat lozenge
•    drinking hot water with honey and lemon — a simple and effective home remedy.