Cholecalciferol (OSTEON D3) is one of the most useful nutritional tools we have at our disposal for improving overall health. This vitamin is unique because cholecalciferol (OSTEON D3) is a vitamin derived from 7-dehyrocholesterol; however, Vitamin D3 acquires hormone-like actions when cholecalciferol (OSTEON D3) is converted to 1,25-dihydroxy Vitamin D3 (Calcitriol) by the liver and kidneys. As a hormone, Calcitriol controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D3 is the only vitamin the body can manufacture from sunlight (UVB). Yet, with today’s indoor living and the extensive use of sunscreens due to concern about skin cancer, we are now a society with millions of individuals deficient in life-sustaining bone building and immune modulating Cholecalciferol (OSTEON D3) For more than a century, scientists have recognized that Cholecalciferol (OSTEON D3) is involved in bone health. Research has continued to accumulate, documenting Cholecalciferol (OSTEON D3) ’s role in the reduction of the risk of fractures to a significant degree. The latest research, however, shows that Cholecalciferol (OSTEON D3) deficiency is linked to a surprising number of other health conditions such as depression, back pain, cancer, both insulin resistance and pre-eclampsia during pregnancy, impaired immunity and macular degeneration.

For Doctors

OSTEON D3 Chewable tablet

 Each Uncoated Chewable Tablet contains:

Cholecalciferol IP (as stabilized) ……………… 60000 IU

OSTEON D3 Oral Drops

 Each ml contains:

Cholecalciferol IP  …………………. 800 IU

in flavored palatable base

Mechanism of Action

Absorption: Well absorbed from the GI tract. Presence of bile is essential for adequate intestinal absorption. Hence absorption may be decreased in patients with decreased fat absorption.
Distribution: Bound to a specific α-globulin. Can be stored in adipose & muscle tissue for long periods of time. Slowly released from storage sites & skin where it is formed in the presence of sunlight or uv light. May distribute into breast milk.
Metabolism: Hydroxylated in the liver by the enzyme vitamin D 25-hydroxylase to form 25-hydroxycholecalciferol (calcifediol). Further hydroxylated in the kidneys by the enzyme vitamin D1-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol). Further metabolism also occurs in the kidneys, including the formation of the 1,24,25-trihydroxy derivatives.
Excretion: Mainly in the bile & faeces with only small amounts appearing in urine.


Vitamin D deficiency

Treating weak bones (osteoporosis),

Bone pain (osteomalacia),

Bone loss in people with a condition called hyperparathyroidism

Inherited disease (osteogenesis imperfecta)

Preventing falls and fractures

Bone loss  due to Kidney failure (renal osteodystrophy)

 high cholesterol



Mmuscle weakness,

Rheumatoid arthritis

Chronic obstructive pulmonary disease COPD



Premenstrual syndrome (PMS)

Tooth and gum disease.

Skin conditions including vitiligo, scleroderma psoriasis, actinic keratosis, and lupus vulgaris.

Boosting the immune system

Preventing autoimmune diseases

Preventing cancer.

Dosages & Administration

For Adults

For vitamin D deficiency an oral dose of 60,000 IU of vitamin D once per week for 8 weeks. To maintain vitamin D sufficiency, the patient should receive either 60,000 IU of vitamin D once or twice per month thereafter.

For Children & Adolescent

Children and teens need 10 times more than the recommended dose of vitamin D which is 200 IU per day for Vitamin Deficiency

Adverse Drug Reaction

Hyperphosphataemia or hypercalcaemia (in excessive intake). Associated effects of hypercalcaemia include hypercalciuria, ectopic calcification, & renal & CV damage.

Drug Interaction

Increased risk of hypercalcaemia if given with thiazide diuretics, calcium or phosphate. Antiepileptics (e.g. carbamazepine, phenobarbitone, phenytoin  & primidone) may increase vitamin D requirements. Rifampicin & isoniazid may reduce efficacy of vitamin D. Corticosteroids may counteract the effect of vitamin D. Digoxin  or any cardiac glycoside. Reduced absorption when taken with cholestyramine, colestipol, mineral oil, orlistat. Ketoconazole.

Warning & Precaution

Excessive intake may lead to development of hyperphosphataemia or hypercalcaemia. Infants, renal impairment or calculi, heart disease. Monitor plasma phosphate & calcium level. Pregnancy, lactation.

Product Presentation

Tablet Osteon D3  4’s / 100.00

Drops Osteon D3 15ml / 59.00

For Patients
What is cholecalciferol (OSTEON D3)?

OSTEON D3( Cholecalciferol) is a vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

OSTEON D3( Cholecalciferol) is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones.

Cholecalciferol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about cholecalciferol (OSTEON D3)?

You should not use cholecalciferol (OSTEON D3) if you have high levels of calcium or vitamin D in your blood, or if you have any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

What should I discuss with my healthcare provider before taking cholecalciferol (OSTEON D3)?

You should not use cholecalciferol (OSTEON D3) if you have ever had an allergic reaction to vitamin D, or if you have:

·         high levels of calcium in your blood (hypercalcemia);

·         high levels of vitamin D in your body (hypervitaminosis D); or

·         any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

To make sure you can safely take cholecalciferol (OSTEON D3) ,  tell your doctor if you have any of these other conditions:

·         heart disease;

·         kidney disease; or

·         an electrolyte imbalance.

Your cholecalciferol (OSTEON D3)  dose needs may change if you are pregnant or breast-feeding. Tell your doctor if you are pregnant or plan to become pregnant during treatment, or if you are breast-feeding a baby.

How should I take cholecalciferol (OSTEON D3)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. The chewable tablet must be chewed before you swallow it.

Cholecalciferol (OSTEON D3) is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition.

Store at room temperature away from moisture, light, and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while taking cholecalciferol (OSTEON D3)?

Do not take other vitamin or mineral supplements unless your doctor has told you to.

Avoid using calcium supplements or antacids without your doctor's advice. Use only the specific type of supplement or antacid your doctor recommends.

Cholecalciferol (OSTEON D3) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking cholecalciferol (OSTEON D3) and call your doctor at once if you have:

·         thinking problems, changes in behavior, feeling irritable;

·         urinating more than usual;

·         chest pain, feeling short of breath; or

·         early signs of vitamin D overdose (weakness, metallic taste in your mouth, weight loss, muscle or bone pain, constipation, nausea, and vomiting).

What other drugs will affect cholecalciferol (OSTEON D3)?

Ask a doctor or pharmacist if it is safe for you to use cholecalciferol (OSTEON D3) if you are also using any of the following drugs:

·         seizure medication;

·         cholestyramine, colestipol;

·         steroids;

·         digoxin; or

·         A diuretic or "water pill."

This list is not complete. Other drugs may interact with cholecalciferol (OSTEON D3), including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

·         Your healthcare provider can provide more information about cholecalciferol (OSTEON D3)