Each film coated tablet contains:
1250 mg calcium carbonate from an
inorganic sources of Oyster shell
eq. to elemental calcium…….500 mg
Calcitriol ………………………….0.25 mcg
Magnesium Hydroxide eq. to
El. Magnesium…………………….100 mg
Zinc Sulphate Monohydrate Eq. to
El Zinc…………………………………….7.5 mg
- Mechanism of action
Absorption Calcium carbonate: About 15-25% gets absorbed in the GI tract. Converted to calcium chloride by gastric acid. Vitamin D well-absorbed in the GI tract in the presence of bile. Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum.
40% of magnesium intake absorbed in the small intestine, 5% absorbed in the large intestine and 55% leaving the body as waste
Distribution The vast majority of total body calcium (>99%) is present in the skeleton as calcium-phosphate complexes, primarily as hydroxyapatite. Vitamin D binds to receptors located throughout the body..Zinc is stored primarily in red and white blood cells, but also in the muscle, bone, skin, kidney, liver, pancreas, retina, and prostate. One half of body Mg is in bone, one-fourth is in muscle and one-fourth is in soft tissue. About 25% to 30% of total plasma Mg is bound to protein, 10% to 15% circulates in complex form and 55% to 60% is ionized
Excretion Calcium leaves body in faeces mainly. vitamin D and metabolites are mainly excreted in the bile and faeces. Zinc is widely distributed throughout the body and excreted mainly in the feces and only traces are found in the urine since kidney has little role in regulating body Zn content. Magnesium is excreted in urine.
During the active phase of growth and development of the skeleton
I.e. childhood, adolescence and early adulthood; pregnancy and lactation
Prevention and treatment of osteoporosis, particularly in women after menopause and elderly men;
Fractures and immobilization due to prolonged illness;
Long-term steroid therapy
Dietary deficiencies i.e. malnutrition and weight-control dieting.
Treatment of hypocalcaemia – hyperparathyroidism, Osteomalacia (adults), rickets (infants, children), renal Osteodystrophy, chronic kidney disease
- Dosages & Administration
Two Tablets per day with a main meal in divided dose. Swallow with water or a cold drink. Not to be chewed. Do not exceed the recommended intake. OSTEON-CT can be continued for as long as required.
- Adverse Drug Reaction
OSTEON-CT is absolutely safe & side effects may rarely occur like Diarrhea nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, change in the amount of urine, bone/muscle pain, headache, increased thirst, increased urination, weakness, tiredness, fast/pounding heartbeat. It also may cause chills and fever, gastrointestinal distress, sore throat, ulcers or sores in the mouth or throat and fatigue and weakness. Calcitriol in OSTEON-CT -CT has a higher risk of inducing hypocalcaemia than Vitamin D. A very serious allergic reaction to this drug is rare. However give immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
- Drug Interaction
Calcium can decrease the absorption of other drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), bisphosphonates (e.g., alendronate), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin). Also, certain medications can decrease the absorption of vitamin D (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat). Therefore, separate your doses of these medications as far as possible from your doses of calcium/vitamin D. Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications. Vitamin D is very similar to calcitriol. Do not use medications containing calcitriol while using vitamin D.
- Warning & Precaution
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products (such as calcitriol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Avoid this medicine in high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel disease, kidney stones, kidney disease, certain immune system disorder (sarcoidosis), liver disease, certain bowel diseases (Crohn's disease, Whipple's disease), little or no stomach acid (achlorhydria), low levels of bile, untreated phosphate imbalance.This medication passes into breast milk. Consult your doctor before breast-feeding. Magnesium should be given very cautiously in the presence of serious impairment of renal function since it is excreted almost entirely by the kidneys.
- Product Presentation
Tablet / 10’s / 90.00